Course on Epidemiologic Research and New Directions
     
 

Course Program

 

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Session

Day/Time

Session Topic and Speaker

E Saturday
12:45-13:45
Use of the Whole Cohort in the Analysis of Case-Control and Case-Cohort Studies
Norman Breslow
Professor of Biostatistics
Department of Biostatistics, University of Washington, Seattle, WA, United States
Abstract:
The presentation will start with a brief introduction to two phase stratified designs for sampling subjects from a large cohort for purposes of additional data collection. A general framework for the analysis of data from such studies will be presented that integrates the traditional model based approach of the biostatistician with the design based approach of the survey statistician. The goal is to incorporate into the analysis useful information for subjects in the main cohort, information that is often ignored in published reports. Programs and data from the National Wilms Tumor Study (NWTS), available from the instructor's website, will be used to illustrate the methodology. Several packages and programs developed for the freely available R statistical package will be described, in particular the R survey package developed by my colleague Thomas Lumley. Several methods of adjustment of inverse probability sampling weights are available that can enhance the recovery of information from main cohort. These will be illustrated using the NWTS data. The instructor's plenary lecture during the main meeting will present further applications of these methods to data from a large cohort study of coronary heart disease.

Link to material prepared for the Course:
http://faculty.washington.edu/norm/IEA08.html
Recommended Literature:

1) A book chapter on case-control studies I wrote for the recent Springer Handbook of Epidemiology. This falls in the category "could benefit from in general." [View Document]

2) An article by myself and a former student (Chatterjee) from Applied Statistics, 1999. This is the most accessible paper (other than the one submitted above) for a general epidemiology audience on the work I have been doing in this area. Methods have progressed substantially since this was written. [View Document]

3) A more technical paper by Borgan and colleagues from Lifetime Data Analysis (2000) [View Document] that describes the standard Horwitz-Thompson approach to analysis of stratified case-cohort studies. I think this is likely to be beyond the comprehension of most attendees. A major purpose of my presentation is to introduce the attendees to the availability of the R survey package developed by my colleague and co-author Thomas Lumley, and how it may be applied to case-control and case-cohort studies. Participants can access this package and some useful background materials themselves via the Comprehensive R Archive Network (CRAN) as follows:

1)
Navigate to the R Project home page: http//www.r-project.org/
2)
Select a nearby CRAN mirrow site (these are listed by country)
3)
From the CRAN site select "Packages" under "Software"
4)
Click on "S" and then on "survey"
5)
Download the Reference manual "survey.pdf" and the vignette "Two-phase designs in epidemiology". It is best to install the package itself from within R following instructions.
6)
Another relevant package available from the CRAN site is the NestedCohort package developed by Hormuzd Katki. This also contains a Reference Manual and a tutorial. I hope to be able to compare and contrast results obtained using both packages during my presentation.

Those who are interested can download the entire R package from the CRAN site (it is a free program) and could in principal have all this installed on their laptops for discussion during the session.

Biography:
Read this document on Scribd: Biosketch Olsen
Norman Breslow is Professor of Biostatistics at the University of Washington, Seattle and Member of the Public Health Sciences Division of the Fred Hutchinson Cancer Research Center. A former staff member of the International Agency for Research on Cancer, he is co-author with Professor Nicholas Day of two influential IARC monographs on the design and analysis of case-control and cohort studies. A founding member of the National Wilms Tumor Study Group in 1969, he currently serves as principal investigator on a long term follow-up study of former patients.

Professor Breslow is a member of the Institute of Medicine of the National Academy of Sciences and a former President and Honorary Life Member of the International Biometric Society.
 
     

 

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Hosted and supported by the International Epidemiological Association

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18th World Congress of Epidemiology
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