Use of the Whole Cohort in the Analysis of Case-Control and Case-Cohort Studies •Norman Breslow Professor of Biostatistics
Department of Biostatistics, University of Washington, Seattle, WA, United States
Recommended Literature:
3) A more technical paper by Borgan and colleagues from Lifetime Data Analysis (2000) [View Document] that describes the standard Horwitz-Thompson approach to analysis of stratified case-cohort studies. I think this is likely to be beyond the comprehension of most attendees. A major purpose of my presentation is to introduce the attendees to the availability of the R survey package developed by my colleague and co-author Thomas Lumley, and how it may be applied to case-control and case-cohort studies. Participants can access this package and some useful background materials themselves via the Comprehensive R Archive Network (CRAN) as follows:
Select a nearby CRAN mirrow site (these are listed by country)
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From the CRAN site select "Packages" under "Software"
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Click on "S" and then on "survey"
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Download the Reference manual "survey.pdf" and the vignette "Two-phase designs in epidemiology". It is best to install the package itself from within R following instructions.
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Another relevant package available from the CRAN site is the NestedCohort package developed by Hormuzd Katki. This also contains a Reference Manual and a tutorial. I hope to be able to compare and contrast results obtained using both packages during my presentation.
Those who are interested can download the entire R package from the CRAN site (it is a free program) and could in principal have all this installed on their laptops for discussion during the session.
1) A book chapter on case-control studies I wrote for the recent Springer Handbook of Epidemiology. This falls in the category "could benefit from in general." [View Document]
2) An article by myself and a former student (Chatterjee) from Applied Statistics, 1999. This is the most accessible paper (other than the one submitted above) for a general epidemiology audience on the work I have been doing in this area. Methods have progressed substantially since this was written. [View Document]
Norman Breslow is Professor of Biostatistics at the University of Washington, Seattle and Member of the Public Health Sciences Division of the Fred Hutchinson Cancer Research Center. A former staff member of the International Agency for Research on Cancer, he is co-author with Professor Nicholas Day of two influential IARC monographs on the design and analysis of case-control and cohort studies. A founding member of the National Wilms Tumor Study Group in 1969, he currently serves as principal investigator on a long term follow-up study of former patients.
Professor Breslow is a member of the Institute of Medicine of the National Academy of Sciences and a former President and Honorary Life Member of the International Biometric Society.
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